Faropenem sodium

CAS No. : 122547-49-3

Faropenem sodium,122547-49-3
Product Details
Cat No:A001236
Molecular Formula:C12H14NO5S Na
Molecular Weight:335.31
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Water Content (Karl Fisher):≤14.0%
Optical Rotation:+145° to +150°
Cat No:A001236
Cas No:122547-49-3
Product-Name:Faropenem sodium
Faropenem sodium is a broad spectrum beta-lactam antibiotic belonging to the penem antibiotic class. Faropenem sodium is freely soluble in water (>20mg/mL).
β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like other antibiotics in the penem class, faropenem sodium is highly resistant to β-lactamases and some extended spectrum β-lactamases (ESBLs).
Milazzo, I. /Faropenem, a New Oral Penem: Antibacterial Activity against Selected Anaerobic and Fastidious Periodontal Isolates./ Journal of Antimicrobial Chemotherapy
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