ρ-Da1a – AdTx1

CAS No. :

ρ-Da1a – AdTx1,
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:P000406
Molecular Formula:C310H481N87O100S8
Target:Selective antagonist of the alpha(1A)-adrenoceptor
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Appearance: <hite lyophilized solid
Purity rate: > 98 %
Disulfide bonds: Cys3-Cys24, Cys17-Cys42, Cys46-Cys57, Cys58-Cys63
Length (aa): 65
Cat No:P000406
Product-Name:ρ-Da1a – AdTx1
AdTx1 (rho-Da1a – ρ-Da1a) is a 65 amino-acid peptide originally isolated from the venom of the green mamba, an African snake (Dendroaspis angusticep). AdTx1 is stabilized by four disulfide bridges and belongs to the family of the three-finger-fold peptide. AdTx1 has subnanomolar affinity (K(i)= 0.35 nM) and high specificity for the human alpha(1A)-adrenoceptor subtype and is 1000 times more potent on this subtype than on other adrenoceptor subtypes. AdTx1 is a potent relaxant of smooth muscles.
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