Is Caspofungin Used against Fungal Infection?
Abstract
Caspofungin is a new type of echinocandin antifungal drug. As a prescription drug, it is mainly used to treat invasive candidiasis, invasive aspergillosis that is ineffective or intolerable to other treatments, and empirical treatment of suspected fungal infections in patients with neutropenia and fever. As a representative of a new class of echinocandins, caspofungin will become a research hotspot of systemic antifungal agents because of its obvious advantages of high selectivity, good antibacterial activity, high safety, less drug resistance and expiration of patent protection.
What is Caspofungin
Caspofungin is a new type of echinocandin antifungal drug. As a prescription drug, it is mainly used to treat invasive candidiasis, invasive aspergillosis that is ineffective or intolerable to other treatments, and empirical treatment of suspected fungal infections in patients with neutropenia and fever. As a representative of a new class of echinocandins, caspofungin will become a research hotspot of systemic antifungal agents because of its obvious advantages of high selectivity, good antibacterial activity, high safety, less drug resistance and expiration of patent protection. Fungi are a kind of eukaryotic microorganisms widely existing in nature. Commonly, the human body is infected by fungi which causes diseases. Clinically, fungal infection is divided into superficial fungal infection and deep fungal infection according to the depth of fungal invasion. The former is mainly caused by Epidermophyton, Trichophyton and Microsporum. The main symptoms are tinea capitis, tinea corporis, tinea versicolor and onychomycosis. It is a common multiple-infection disease and is not easy to cause death. Deep fungal infection is also known as invasive fungal infection, which can penetrate the superficial tissues of the sterile human body and invade the deep tissues and organs of the human body. There are many chances for human body to suffer from fungal invasion, but whether the disease will occur depends mainly on the interaction of external pathogenic factors and human immunity. In recent years, with the advancement of medical technology, the gradual popularization of hematopoietic stem cells, solid organ transplantation and catheter intervention, and the widespread application of broad-spectrum antibiotics, immunosuppressants and chemotherapy drugs, the incidence of deep fungal infections has shown a significant upward trend. This has led to the continuous improvement of medical standards, and Candida and Aspergillus are important pathogenic sources of invasive fungal infections in fungal infection diseases, invading internal organs and hematological skeletal systems; cryptococcus neoformans, Pneumocystis carinii, Sporothrix and Histoplasma also showed strong invasive pathogenicity. The most common routes of infection for invasive fungal diseases are surgical wounds, digestive system and respiratory system, followed by urinary tract and blood. It causes great harm, poor prognosis and high mortality, and has become one of the main causes of death in critically ill patients. Systemic antifungal drugs must be used clinically. In recent years, the incidence of invasive fungal infection has been increasing. The clinical treatment methods for antifungal infection mainly include preventive treatment, empirical treatment, diagnosis-driven treatment and target treatment. In the early stage of deep fungal infection, the accuracy of diagnosis directly affects the selection of antifungal drugs and the improvement of efficacy. Improving the accuracy of diagnosis is conducive to reducing the difficulty of empirical antifungal therapy and antifungal drug selection, thus effectively preventing fungal resistance. However, the sensitivity and specificity of traditional diagnostic methods for deep fungal infection are not high, and the detection rate is low. And the early symptoms of deep fungal infection are not obvious, in clinical diagnosis and targeted treatment are difficult, resulting in deep fungal infection mortality has been at a high level. Critically ill patients with suspected fungal infection, in the case of clinical undiagnosed, generally take empirical treatment. In the treatment of invasive fungal infections, whether it is preventive treatment, empirical treatment, or target treatment, it is very important to choose a reasonable, efficient, safe and broad-spectrum drug. Antifungal drugs that kill or inhibit the growth or reproduction of fungi in clinical practice can be roughly divided into polyenes, azoles, allylamines, nucleoside analogues, echinocandins, etc. However, it is generally only applicable to superficial fungal infections, while invasive fungal infections (deep fungal infections) require systemic medication or even combination medication. The most commonly used are polyenes (amphotericin B and its liposomes, etc.), azoles (fluconazole, itraconazole and voriconazole, posaconazole, etc.) and echinocandins (caspofungin, micafungin and anidulafungin, etc.).
Caspofungin is a lipopeptide compound and the first echinocandin antifungal drug. It was licensed by the US FDA in 2001 for the treatment of invasive fungal infections in adults and children aged 3 months and above. As a representative of a new class of echinocandins, caspofungin possesses the unique antifungal mechanism of echinocandins.
Caspofungin has both bactericidal activities against Candida and antibacterial activity against Aspergillus. It is clinically useful for the treatment of Candida infections and candidemia, as well as invasive aspergillosis (IA) that is ineffective or intolerable to other treatments, such as amphotericin B, amphotericin B liposomes, or itraconazole. It can also be used to treat suspected fungal infections in patients with persistent febrile neutropenia. Caspofungin mainly inhibits the synthesis of the fungal cell wall by non-competitive inhibition of β- (1,3) -D-glucan synthase and does not affect mammalian cells. It is not metabolized by liver drug-metabolizing enzymes. The risk of drug-drug interaction is low and the safety is good. Evidence has shown that echinocandins have higher treatment success rates and lower patient mortality than triazoles and polyenes in patients with severe invasive Candida infections. Based on this, the ' Clinical Practice Guidelines for Candidiasis ' and the ' Chinese Expert Consensus on Diagnosis and Treatment of Adult Candidiasis ' issued by the American Society for Infectious Diseases in 2016 recommended caspofungin as the first-line treatment for invasive candidiasis (IC).
