Filovirus

Filoviruses, which include notorious pathogens like Ebola and Marburg viruses, are known for causing severe hemorrhagic fevers with high mortality rates. These viruses target multiple cell types, leading to widespread tissue damage and immune system dysregulation. Filoviruses are enveloped, with a single-stranded RNA genome that facilitates rapid mutation and evasion of host immune responses. Therapeutic targeting of filoviruses involves antiviral drugs that inhibit viral entry, replication, and transcription. Development of vaccines is also critical, with some success in recent Ebola outbreaks. Research focuses on understanding the virus-host interactions to develop more effective therapies and preventive measures, crucial for controlling outbreaks and reducing fatalities.