FKBP

FKBP (FK506 binding protein) refers to a family of proteins that bind to immunosuppressive drugs such as FK506 (tacrolimus) and rapamycin. These proteins are involved in a wide range of cellular functions including protein folding and trafficking, signal transduction, and immune response regulation. FKBPs act as peptidyl-prolyl isomerases that catalyze the cis-trans isomerization of proline residues in peptide bonds, influencing protein conformation and function. Due to their role in modulating immune responses and cell growth, FKBPs are important targets in treating autoimmune diseases and cancers. Pharmacological agents targeting FKBPs can help manage diseases by altering immune function or by affecting the growth of cancerous cells.