RIP kinase

RIP kinases (Receptor-Interacting Protein kinases) are a family of serine/threonine kinases that play crucial roles in signaling pathways controlling cell death, survival, and inflammation. These kinases are integral to the necroptosis pathway, a form of programmed necrosis, and also impact other forms of cell death like apoptosis and pyroptosis. RIP kinases, particularly RIPK1 and RIPK3, mediate cellular responses to stress, toxins, and infection by interacting with various receptors, including those engaged by tumor necrosis factor (TNF). Due to their significant role in inflammation and cell death, RIP kinases are promising targets for drug development aimed at treating inflammatory and auto-immune diseases, as well as certain cancers where necroptosis is implicated.