TNF Receptor

The TNF receptor (TNFR) family comprises a group of cell surface receptors that are pivotal in mediating immune responses. These receptors bind tumor necrosis factor (TNF), a cytokine involved in systemic inflammation, which plays a crucial role in the immune system's defense against infection and its response to injury. Activation of TNFR triggers various cellular processes including apoptosis, survival, inflammation, and differentiation. Due to its central role in inflammation and immune regulation, the TNF receptor pathway is a significant target for therapeutic intervention in autoimmune diseases such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. Drugs that block TNFR signaling, like TNF inhibitors, are effective in reducing inflammation and halting disease progression.