LRRK2

Leucine-rich repeat kinase 2 (LRRK2) is a multifunctional enzyme implicated in the regulation of various cellular processes including mobility, autophagy, and mitochondrial function. LRRK2 is particularly notable for its role in Parkinson’s disease (PD). Mutations in the LRRK2 gene are one of the most common genetic causes of PD, leading to neurodegeneration and typical Parkinsonian symptoms. Due to its central role in the pathogenesis of PD, LRRK2 is a significant target for therapeutic intervention. Inhibiting LRRK2 activity presents a promising strategy to mitigate the progression of Parkinson's disease, and research in this area is actively pursuing drug development to specifically target this kinase in affected individuals.