Mitophagy

Mitophagy is a specialized form of autophagy that specifically targets mitochondria for degradation and recycling within cells. This process is crucial for maintaining cellular health by removing damaged or dysfunctional mitochondria, thus preventing potential harmful effects, including oxidative stress and apoptosis. Mitophagy is regulated by several key proteins, including PINK1 and Parkin, which detect and label damaged mitochondria for disposal. Disruption in mitophagy is linked to various diseases, particularly neurodegenerative disorders like Parkinson's and Alzheimer's, where mitochondrial dysfunction plays a significant role. Targeting mitophagy pathways offers a therapeutic potential to enhance mitochondrial quality control, potentially slowing disease progression and improving cellular function in mitochondrial and neurodegenerative diseases.