APC

APC (Adenomatous Polyposis Coli) is a crucial tumor suppressor gene that plays a significant role in the regulation of cell growth and apoptosis through its involvement in the Wnt signaling pathway. The protein product of the APC gene helps in the breakdown of beta-catenin, a key component in cell growth regulation. Mutations in the APC gene are commonly associated with colorectal cancers, particularly in familial adenomatous polyposis (FAP), where individuals develop numerous polyps that have a high probability of turning malignant. APC's role in cellular processes and cancer makes it a critical target for genetic and pharmacological research, aiming to develop therapies that can correct or compensate for its dysfunctional signaling in cancer.