ATF6

ATF6 (Activating Transcription Factor 6) is a crucial component of the endoplasmic reticulum (ER) stress response, specifically involved in the unfolded protein response (UPR). Under conditions of ER stress, where misfolded proteins accumulate, ATF6 is activated and translocates from the ER to the Golgi apparatus, where it is processed into an active form. This active ATF6 then enters the nucleus and upregulates the expression of genes that enhance the protein folding capacity of the ER and promote cell survival. Given its role in managing cellular stress and maintaining proteostasis, ATF6 is a potential therapeutic target for diseases characterized by ER stress, including neurodegenerative disorders, diabetes, and cancer.