LIM Kinase (LIMK)

LIM Kinase (LIMK) is an essential enzyme involved in the regulation of the actin cytoskeleton, crucial for various cellular processes such as morphology, motility, and division. LIMK functions by phosphorylating cofilin, a protein that disassembles actin filaments, thereby controlling actin dynamics. There are two main isoforms, LIMK1 and LIMK2, each having distinct but overlapping roles in cells. Dysregulation of LIMK activity has been implicated in several pathological conditions including cancer, neurological disorders, and cardiovascular diseases. Because of its key role in actin filament regulation and associated cellular functions, LIMK presents a promising target for therapeutic intervention in diseases where abnormal cell migration and invasion are factors.