PAK

p21-activated kinases (PAKs) are a family of serine/threonine protein kinases that play pivotal roles in a variety of cellular processes, including cytoskeletal reorganization, cell motility, survival, and proliferation. PAKs are activated by interaction with small GTPases of the Cdc42 and Rac families, which are critical in cell signaling pathways. Due to their central role in these signaling pathways, PAKs have been identified as promising therapeutic targets for the treatment of cancer and other diseases characterized by abnormal cell migration and proliferation, such as certain cardiovascular diseases and neurological disorders. Inhibiting PAK activity has the potential to disrupt these pathological processes, offering a strategic point of intervention in disease treatment and management.