Sirtuin

Sirtuins are a family of NAD+-dependent enzymes known for their role in regulating cellular health and aging. They modulate various metabolic processes including DNA repair, gene expression, and mitochondrial function. Sirtuins influence longevity in several species and are linked to the aging process in humans. There are seven known isoforms in humans (SIRT1 to SIRT7), each with distinct functions and localization within the cell. SIRT1, for instance, is involved in stress resistance and inflammation reduction, whereas SIRT3 is primarily associated with mitochondrial function. Due to their broad regulatory roles, sirtuins are attractive targets for treating age-related diseases, metabolic syndrome, and neurodegenerative disorders. Their modulation holds potential for therapeutic interventions in aging and metabolic health.