SRPK

SRPK (Serine/Arginine Protein Kinase) refers to a family of protein kinases, including SRPK1 and SRPK2, which primarily phosphorylate serine residues in arginine-serine-rich (RS) domains. These domains are critical components of splicing factors, proteins essential for RNA splicing—a key process in gene expression regulation. The phosphorylation activity of SRPKs enhances the splicing factors' interaction with both the spliceosome and pre-mRNA, thereby influencing alternative splicing decisions. This modulation is crucial for the development of the nervous system and various cellular differentiation processes. Dysregulation of SRPK activity is implicated in numerous diseases, including cancer and neurodegenerative disorders, making SRPK a significant target for therapeutic intervention.