Arp2/3 Complex

The ARP2/3 complex is a critical actin nucleation core that initiates the growth of new actin filaments, primarily responsible for creating the branched actin networks within cells. This complex comprises seven proteins, including ARP2 and ARP3, which mimic actin's structure to start new filament branches. Its activity is pivotal in cellular processes such as migration, endocytosis, and maintaining the integrity of the cytoskeleton. Activation of ARP2/3 is tightly regulated by nucleation-promoting factors, linking signaling pathways to cytoskeletal rearrangement. Given its essential role in cell dynamics and movement, ARP2/3 has significant implications in cancer metastasis and other diseases involving cell motility, making it a valuable target for therapeutic intervention.