Leukotriene Receptor
Leukotriene receptors are G protein-coupled receptors that bind leukotrienes, potent inflammatory mediators produced by the metabolism of arachidonic acid via the lipoxygenase pathway. There are two primary types of leukotriene receptors, CysLT1 and CysLT2, which are crucial in mediating the effects of leukotrienes involved in asthma, allergic rhinitis, and other inflammatory responses. CysLT1 receptors, in particular, are a key target for asthma therapies; antagonists of this receptor, such as montelukast, help reduce bronchoconstriction, airway inflammation, and mucus production. Targeting these receptors provides significant therapeutic benefits in managing and treating conditions characterized by chronic inflammation and allergic reactions.