mAChR

Muscarinic acetylcholine receptors (mAChR) are a subgroup of acetylcholine receptors that are G protein-coupled and responsive to the neurotransmitter acetylcholine. These receptors play crucial roles in a wide range of central and peripheral physiological functions, including modulation of neurotransmission, regulation of heart rate, smooth muscle contraction, and glandular secretion. There are five subtypes of muscarinic receptors, M1 through M5, each with distinct signaling mechanisms and tissue distributions. Targeting mAChR with specific agonists or antagonists can treat various medical conditions, such as overactive bladder, chronic obstructive pulmonary disease (COPD), and some symptoms of Parkinson's disease, by modulating the parasympathetic nervous system's activity.