Neurokinin Receptor

Neurokinin receptors are a group of G protein-coupled receptors that bind neuropeptides such as substance P, neurokinin A, and neurokinin B. These receptors are integral to the regulation of several biological processes, including pain perception, inflammation, and emotional responses. Classified into three main types—NK1, NK2, and NK3—each receptor has a preference for different neuropeptides. NK1 receptors predominantly bind substance P and are heavily implicated in pain transmission and modulation, as well as in stress and anxiety mechanisms. Because of their central role in pain pathways, NK1 receptors are particularly significant targets for pharmaceutical research, aiming to develop treatments for pain relief and psychiatric conditions.