P2Y Receptor

P2Y receptors are a family of G protein-coupled receptors responsive to nucleotides like ATP and ADP. They play critical roles in various physiological processes including platelet aggregation, immune responses, inflammation, and vascular tone regulation. There are several subtypes of P2Y receptors, such as P2Y1, P2Y2, P2Y6, and P2Y12, each with specific agonists and distinct functional roles across different tissues. P2Y12 receptors, for instance, are particularly important in blood clotting and are the targets of antiplatelet drugs like clopidogrel. By influencing cellular responses through intracellular calcium mobilization and inhibition of adenylate cyclase, P2Y receptors are integral in both health and disease, offering potential therapeutic targets for conditions like thrombosis and inflammation.