Prostaglandin Receptor

Prostaglandin receptors are a diverse group of G protein-coupled receptors that respond to prostaglandins, lipid compounds involved in various physiological functions, and inflammatory processes. These receptors are categorized based on their binding affinity to different prostaglandins like PGE2, PGD2, PGF2α, PGI2 (prostacyclin), and thromboxane A2. Each receptor subtype (e.g., EP1, EP2, EP3, EP4 for PGE2) triggers specific cellular responses influencing pain perception, inflammation, vasodilation, and thrombosis among other processes. Prostaglandin receptors are crucial in reproductive physiology, gastric mucosal protection, and renal function. They are key targets in the treatment of pain, inflammation, and vascular diseases, with various drugs designed to modulate their activity.