FLAP

FLAP (5-Lipoxygenase-activating protein) is an essential regulatory component in the biosynthesis of leukotrienes, potent lipid mediators involved in inflammation, allergic reactions, and asthma. It functions by facilitating the transfer of arachidonic acid to 5-lipoxygenase (5-LO), the enzyme responsible for the initial steps in leukotriene production. FLAP is integral for the proper localization and activation of 5-LO within cellular membranes. Its action is critical in the pathophysiology of diseases characterized by inflammation and allergic responses. Inhibiting FLAP has become a target for drug development aiming to mitigate conditions like asthma and other inflammatory diseases by curbing the production of leukotrienes, thus reducing inflammation and associated symptoms.