IFNAR

IFNAR, short for Interferon-alpha/beta receptor, comprises two subunits: IFNAR1 and IFNAR2, and is essential for the cellular response to type I interferons. These cytokines are crucial for antiviral defense, immune modulation, and cell growth regulation. The binding of interferon-alpha or beta triggers IFNAR activation, leading to the activation of the JAK-STAT signaling pathway. This cascade promotes the transcription of genes that inhibit viral replication, enhance immune cell activity, and modulate cell growth. Due to its pivotal role in immune response and inflammation, IFNAR is a significant target in the treatment of various autoimmune diseases and certain types of cancer, offering potential pathways for therapeutic intervention.