Salt-inducible Kinase (SIK)

Salt-inducible kinases (SIKs) are a subfamily of the AMP-activated protein kinase (AMPK) family, involved in crucial cellular processes like metabolism, gene expression, and cell survival. These serine/threonine kinases respond to changes in cellular energy levels and stress, thereby influencing metabolic homeostasis. SIKs are particularly important in regulating the activity of key transcriptional coactivators and are also involved in the immune response and circadian rhythm regulation. Due to their roles in metabolism and inflammation, SIKs are promising therapeutic targets for metabolic disorders such as diabetes and obesity, as well as inflammatory diseases. Research into SIK inhibitors is an active area aiming to develop novel treatments for these conditions.