JAK/STAT Signaling

A JAK/STAT signaling pathway is highly conserved from slime molds and worms to mammals. JAK/STAT signal pathway is the core of the cytokine receptor signal. It is a super-family composed of more than 30 trans-membrane proteins, which can recognize specific cytokines and play a key role in blood formation and immune response. A JAK/STAT signaling pathway is a cytokine-stimulated signal transduction pathway discovered in recent years. It enables extracellular chemical signals to pass through the cell membrane and transmit information to the gene promoter on the nuclear DNA, which ultimately leads to changes in the level and activity of DNA transcription in cells. The JAK/STAT signal pathway-related products currently provided can be used for the research of the JAK/STAT signal pathway and related diseases.