EGFR

The Epidermal Growth Factor Receptor (EGFR) is a transmembrane protein that is part of the tyrosine kinase receptor family, playing a critical role in regulating cell growth, survival, proliferation, and differentiation. Overexpression or mutations of EGFR are implicated in the pathogenesis of various types of cancer, including non-small cell lung cancer, colorectal cancer, and breast cancer. Targeting EGFR with specific inhibitors can block the signaling pathways that promote tumor growth and survival. EGFR inhibitors, such as gefitinib, erlotinib, and cetuximab, are used to treat cancers with abnormal EGFR activity. These therapies provide a targeted approach, disrupting cancer progression by directly affecting the tumor cells' molecular pathways.