Pim

PIM kinases (Proviral Integration site for Moloney murine leukemia virus) are a family of serine/threonine kinases, comprising three isoforms: PIM-1, PIM-2, and PIM-3. These kinases are involved in various cellular processes, including cell cycle progression, survival, and apoptosis, primarily by phosphorylating target proteins that regulate these pathways. Overexpression of PIM kinases has been linked to several cancers, such as leukemia, lymphoma, and prostate cancer, due to their role in promoting cell proliferation and survival, as well as resistance to chemotherapy. Targeting PIM kinases with inhibitors represents a promising therapeutic approach to cancer treatment, aiming to reduce tumor growth and overcome drug resistance by modulating these critical survival pathways.