STAT

Signal Transducer and Activator of Transcription (STAT) proteins are a family of transcription factors that play a pivotal role in conveying signals from cytokine and growth factor receptors to the nucleus, where they influence gene expression. STAT proteins are critical for regulating immune responses, cell growth, and differentiation. Dysregulation and persistent activation of certain STAT family members, particularly STAT3 and STAT5, have been linked to various cancers and autoimmune diseases. As a result, STAT proteins are significant targets for therapeutic intervention. Inhibiting STAT signaling pathways offers a strategy to modulate aberrant cell proliferation and immune responses associated with disease states, presenting potential treatments for cancer, inflammatory, and autoimmune disorders.