ERK

Extracellular signal-regulated kinases (ERKs) are crucial components of the mitogen-activated protein kinase (MAPK) signaling pathway, which is essential for regulating cell division, differentiation, and survival. ERKs, particularly ERK1 and ERK2, transmit signals from the cell surface to the nucleus, influencing the expression of genes that drive cell proliferation and survival. Dysregulation of ERK signaling is commonly associated with various cancers and developmental disorders, making ERK a critical target for therapeutic intervention. Inhibiting ERK and its upstream activators offers a potential strategy for controlling unchecked cell growth in cancerous tissues, thus contributing to the development of anti-cancer drugs aimed at this key signaling pathway.