MAP3K

Mitogen-activated protein kinase kinases (MAP3Ks) are key regulatory enzymes at the apex of the MAP kinase signaling cascades, which play pivotal roles in transmitting extracellular signals to intracellular responses. These kinases initiate the phosphorylation cascade that ultimately activates various MAP kinases, influencing cell proliferation, differentiation, apoptosis, and stress responses. Due to their central role in these critical cellular processes, MAP3Ks are linked to the pathogenesis of several diseases, including cancer, inflammatory disorders, and metabolic diseases. Targeting MAP3Ks therapeutically is a promising strategy for modulating abnormal cell signaling pathways to treat these conditions. As such, they are a focus of extensive research aiming to develop specific inhibitors that can selectively modulate their activity.