MAP4K

MAP4K, or Mitogen-Activated Protein Kinase Kinase Kinase Kinase, is a family of serine/threonine kinases that serve as upstream regulators in several critical signaling pathways, including those involving stress responses, apoptosis, and cell differentiation. This kinase family plays a pivotal role in transducing extracellular signals to the MAP kinase cascades, influencing diverse cellular activities. The dysregulation of MAP4K enzymes has been linked to various pathological conditions, including inflammatory diseases and cancer, due to their role in controlling key cellular functions. Targeting MAP4K with specific inhibitors presents a promising therapeutic approach, potentially altering disease progression by modulating the signaling pathways that contribute to the development and maintenance of these conditions.