Mixed Lineage Kinase

Mixed Lineage Kinase (MLK) refers to a family of protein kinases that play a crucial role in transmitting signals within cells. These enzymes are involved in various signaling pathways that regulate cell functions such as growth, development, and stress response. MLKs are particularly significant in their ability to activate the Jun N-terminal kinases (JNK) and p38 MAP kinase pathways, which are critical for cellular responses to environmental stresses and inflammatory cytokines. Dysregulation of MLK activity has been linked to several neurodegenerative diseases, including Alzheimer's and Parkinson's disease, highlighting their potential as targets for therapeutic intervention to modulate disease progression and symptoms.