MNK

MNK, or MAP kinase-interacting serine/threonine-protein kinase, includes two isoforms, MNK1 and MNK2, which are implicated in various cellular processes. These kinases are activated by MAP kinases like ERK and p38, playing a pivotal role in controlling protein synthesis by phosphorylating the eukaryotic initiation factor eIF4E. This phosphorylation affects the translation of specific mRNAs, particularly those involved in cell growth and survival. The role of MNKs in cancer has garnered significant attention, as they can influence tumor growth and resistance to therapy. Thus, MNKs are considered promising targets for cancer treatment, with inhibitors being developed to block their activity and potentially improve patient outcomes in cancer therapies.