p38 MAPK

p38 MAPK (Mitogen-Activated Protein Kinase) is a critical enzyme in the MAPK signaling pathway, playing a pivotal role in cellular responses to stress and inflammatory cytokines. This kinase is involved in various cellular processes, including inflammation, cell cycle regulation, cell death, and differentiation. p38 MAPK is activated by environmental stress, such as UV radiation, heat shock, and cytokines, which in turn triggers the transcription of genes responsible for the inflammatory response and apoptosis. Due to its central role in inflammatory diseases and cancer, p38 MAPK is a significant target for therapeutic intervention. Inhibitors of p38 MAPK are currently being explored to treat diseases like rheumatoid arthritis and psoriasis, where inflammation is a key factor.