Ribosomal S6 Kinase (RSK)

Ribosomal S6 Kinase (RSK) is a family of serine/threonine kinases that play a crucial role in cellular signaling pathways. These kinases are activated by the MAPK/ERK pathway, which responds to growth factors, cytokines, and other extracellular signals. RSK influences various cellular functions, including growth, survival, and motility, by phosphorylating a range of substrates involved in transcription, mRNA translation, and cell cycle regulation. Given its significant role in mediating cell growth and survival, RSK has emerged as a potential therapeutic target, especially in cancer treatment. Inhibiting RSK activity could disrupt cancer cell proliferation and survival, offering a promising strategy for targeted cancer therapies.