5 alpha Reductase

6-alpha reductase is an enzyme that plays a crucial role in the metabolism of hormones within the human body. It is primarily known for converting testosterone, the male sex hormone, into dihydrotestosterone (DHT), a more potent androgen that has significant effects on male development and health. This conversion is critical in prostate growth, hair follicle development, and skin oil production. There are three known isoenzymes of 5-alpha reductase, each with distinct tissue distributions and physiological functions. Inhibitors of this enzyme, such as finasteride and dutasteride, are used clinically to treat conditions like benign prostatic hyperplasia and male pattern baldness by reducing DHT levels. These inhibitors can also have significant effects on hormone-related conditions in both men and women.