Angiotensin-converting Enzyme (ACE)

Angiotensin-converting enzyme (ACE) is a key enzyme in the renin-angiotensin system (RAS), which regulates blood pressure and fluid balance in the body. ACE primarily functions to convert angiotensin I, an inactive peptide, into angiotensin II, a potent vasoconstrictor that raises blood pressure by narrowing blood vessels and stimulating sodium retention in the kidneys. This enzyme is found predominantly in the lungs but also occurs in other tissues. Due to its critical role in blood pressure regulation, ACE is a common target for antihypertensive drugs, such as ACE inhibitors. These medications help lower blood pressure and are beneficial in treating conditions like hypertension, heart failure, and chronic kidney disease.