ATP Citrate Lyase

ATP citrate lyase is a crucial enzyme in cellular metabolism that links the metabolism of carbohydrates and fats. It catalyzes the conversion of citrate, a compound derived from the mitochondria during the citric acid cycle, into acetyl-CoA and oxaloacetate in the cytoplasm. This reaction is vital for the production of acetyl-CoA outside the mitochondria, which is a key precursor for fatty acid synthesis and cholesterol biosynthesis. Thus, ATP citrate lyase plays a significant role in lipid metabolism, especially in liver cells. Inhibitors of this enzyme are being explored as potential therapeutic agents for treating hyperlipidemia, obesity, and related metabolic disorders, highlighting its importance in managing metabolic health.