Fatty Acid Synthase (FASN)

Fatty Acid Synthase (FASN) is a key enzyme complex involved in the synthesis of long-chain fatty acids from acetyl-CoA, malonyl-CoA, and NADPH. This multienzyme complex performs a series of reactions that extend the fatty acid chain, playing a critical role in lipogenesis, the process of converting carbohydrates into fatty acids. FASN is highly active in liver and adipose tissues, where it supports the storage of energy and production of cell membranes. Due to its role in lipid metabolism and overexpression in various cancers, FASN is considered a potential target for anti-obesity and anticancer therapies. Inhibitors of FASN are being explored to disrupt cancer cell growth and manage obesity-related conditions.