Mineralocorticoid Receptor

The mineralocorticoid receptor (MR) is a crucial nuclear receptor in the endocrine system that primarily binds and responds to mineralocorticoids like aldosterone, as well as glucocorticoids to a lesser extent. It plays a vital role in regulating sodium, potassium, and water balance in the body. When activated by its ligands, MR translocates to the nucleus where it influences the expression of specific genes that manage electrolyte balance and blood pressure. This receptor is predominantly found in the kidneys, heart, and certain parts of the brain. Dysregulation of MR activity is linked to conditions such as hypertension, heart failure, and renal pathologies, highlighting its significance in cardiovascular and renal health.