MMP

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that play crucial roles in the remodeling of the extracellular matrix (ECM), which is fundamental for various physiological processes including development, wound healing, and angiogenesis. MMPs are also involved in pathological conditions such as cancer metastasis, arthritis, and fibrosis by degrading ECM components like collagen and elastin. The activity of MMPs is tightly regulated at multiple levels, including transcription, zymogen activation, and inhibition by specific tissue inhibitors of metalloproteinases (TIMPs). Dysregulation of MMP activity can lead to excessive ECM degradation, contributing to disease progression. Research into MMP inhibitors continues as a potential therapeutic approach for these conditions.