NAMPT

NAMPT (Nicotinamide phosphoribosyltransferase) is an enzyme crucial in cellular metabolism, specifically in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a vital coenzyme in redox reactions. NAMPT functions in two forms: intracellular (iNAMPT), which catalyzes the conversion of nicotinamide to nicotinamide mononucleotide (NMN) as a key step in the NAD+ salvage pathway, and extracellular (eNAMPT), which has been implicated in various physiological and pathophysiological processes including inflammation, metabolism, and aging. Elevated levels of NAMPT are associated with several diseases such as cancer, diabetes, and cardiovascular diseases, highlighting its potential as a therapeutic target. NAMPT’s role in extending cellular lifespan also ties it to research on aging and longevity.