SGK

SGK (serum- and glucocorticoid-regulated kinase) is a protein kinase that is highly responsive to serum and glucocorticoids, playing critical roles in regulating ion transport, cell survival, and proliferation. There are three isoforms—SGK1, SGK2, and SGK3—with SGK1 being the most extensively studied. SGK1 influences various cellular functions including sodium and potassium homeostasis through the modulation of ion channels and transporters. It also activates key signaling pathways such as PI3K/Akt and mTOR, which are essential for cell growth and survival. Dysregulation of SGK is associated with several diseases, including hypertension, diabetes, and cancer, making it a potential target for therapeutic intervention in conditions characterized by abnormal cell survival.