PI3K/Akt/mTOR

The PI3K/AKT/mTOR pathway is a crucial signaling network that regulates cell growth, survival, proliferation, and metabolism. PI3K (phosphoinositide 3-kinase) activation triggers AKT (also known as Protein Kinase B), which then stimulates mTOR (mechanistic target of rapamycin), a key regulatory kinase. This pathway is vital for normal cellular functions and responses to environmental cues. However, its dysregulation is commonly associated with cancer, as it can lead to uncontrolled cell growth and resistance to apoptosis. Inhibitors targeting various components of the PI3K/AKT/mTOR pathway are under extensive research and development, offering potential treatments for cancer by curbing the growth and survival of tumor cells. Targeting this pathway is also being explored for diseases like diabetes and cardiovascular disorders due to its role in metabolic regulation.