Btk

Bruton's tyrosine kinase (BTK) is an enzyme found predominantly in hematopoietic cells, playing a vital role in the development and functioning of B cells by mediating signaling pathways involved in their maturation, survival, and activation. Mutations or dysfunctions in BTK are linked to immunological disorders, most notably X-linked agammaglobulinemia (XLA), a condition characterized by a significant reduction in mature B cells and antibodies, leading to increased susceptibility to infections. BTK is also a therapeutic target in various B-cell malignancies such as chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL). BTK inhibitors, like ibrutinib, have revolutionized treatment for these diseases by effectively blocking BTK activity, thereby inhibiting B cell proliferation and survival.