c-Fms

C-FMS, also known as CSF1R (Colony Stimulating Factor 1 Receptor), is a receptor tyrosine kinase that is primarily expressed on the surface of monocytes and macrophages. It plays a crucial role in the regulation of the survival, proliferation, and differentiation of cells within the mononuclear phagocyte system. C-FMS is activated by binding to its ligand, macrophage colony-stimulating factor (M-CSF). This activation is essential for the development and function of macrophages and other related cells, which are important for immune responses and tissue homeostasis. Dysregulation of C-FMS signaling has been implicated in various diseases, including cancers and inflammatory disorders, making it a target for therapeutic interventions aimed at modulating immune responses and tumor progression.