c-Met/HGFR

C-MET, also known as hepatocyte growth factor receptor (HGFR), is a receptor tyrosine kinase that plays a crucial role in cellular processes such as growth, regeneration, and survival. It is activated by binding to its ligand, hepatocyte growth factor (HGF). This interaction triggers a cascade of signaling pathways that promote cell proliferation, migration, and angiogenesis. C-MET is essential for embryonic development and wound healing in adults, but its dysregulation is implicated in the progression of various cancers, including lung, liver, and gastric cancers, through mechanisms like enhanced cell invasion and metastasis. As such, C-MET is a significant target in cancer therapy, with several inhibitors developed to block its activity in tumor cells.