FGFR

Fibroblast Growth Factor Receptors (FGFRs) are a family of receptor tyrosine kinases that play key roles in regulating cell growth, differentiation, migration, and survival. These receptors are activated by binding to fibroblast growth factors (FGFs), initiating a cascade of downstream signaling pathways involved in developmental processes and the maintenance of adult tissue homeostasis. Mutations and dysregulation of FGFRs are implicated in a variety of pathological conditions, including skeletal disorders, cancers, and developmental syndromes. Given their critical role in cell function and development, FGFRs are important targets in cancer therapy, with several FGFR inhibitors developed to treat cancers characterized by FGFR genetic alterations, offering a precision medicine approach to treatment.