PDGFR

Platelet-derived growth Factor Receptors (PDGFRs) are cell surface tyrosine kinase receptors critical for regulating cellular growth, migration, and proliferation, primarily responding to platelet-derived growth factors. These receptors play a significant role in developmental processes and the maintenance of various cell types, including fibroblasts, smooth muscle cells, and certain glial cells in the central nervous system. Abnormal PDGFR signaling is implicated in numerous pathologies such as fibrotic disorders, atherosclerosis, and particularly cancers, where it can drive tumor growth and metastasis. Consequently, PDGFRs are important targets for cancer therapies, with several inhibitors developed to block their activity and thereby hinder the progression of diseases associated with PDGFR signaling anomalies.