ROS Kinase

ROS kinase, also known as c-ros oncogene 1 (ROS1), is a receptor tyrosine kinase that plays a role in cell growth and differentiation. Although its biological function is not fully understood, ROS1 is known to be involved in the development of epithelial, neural, and reproductive tissues. Dysregulation and genetic alterations of ROS1, such as translocations, are implicated in various cancers, including non-small cell lung cancer (NSCLC), gastric cancer, and glioblastoma. These mutations typically lead to constitutive activation of ROS1 signaling, promoting oncogenic processes such as proliferation and survival. As a result, ROS1 has become a significant target for cancer therapy, with specific inhibitors like crizotinib being used to treat ROS1-positive tumors.